Heart & Circulation

Cochrane Vascular needs a Consumer Reviewer to comment on a review investigating short periods of limb blood flow blocking to reduce death and organ injury in people undergoing vascular surgery

Skills / interests: Consumer (public, patient, carer) input

As the population is ageing, more people will experience vascular disease or artery disease, narrowing due to the build-up of fatty deposits or balloon-like bulging of arteries. As an essential treatment strategy for severe artery disease, vascular surgery removes the deposits or repairs the bulge but this carries an increased risk of death and complications. The high risk of surgery is mainly due to the blood flow obstruction and re-saturation involved in the vascular surgery procedure, also known as “ischaemia-reperfusion injury”. Several approaches have been implemented to reduce the surgery risk but with limited effect. The temporary blockage (by a few minutes) of blood flow to an organ can reduce injury in this particular organ (local ischaemic preconditioning) but may also reduce damage in other organs elsewhere (remote ischaemic preconditioning, RIPC). Generally, RIPC is performed by frequently inflating and deflating using a blood pressure cuff placed on the upper arm or leg. As a safe and easy method, the effect of RIPC has been proven to prevent organ damage for heart surgery in animal studies. We wanted to find out whether RIPC versus no RCIP could reduce death and organ injury in people undergoing vascular surgery. If you have personal or carer experience of vascular surgery your comments would be very helpful. Systematic review methodology expertise is not needed. If you are interested, we will send you the review and a comments checklist.  This task will take between two to three hours.  

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